TREM2 enables amyloid β clearance by microglia
نویسندگان
چکیده
منابع مشابه
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β-peptide (Aβ) bind to amyloid plaques and induce their clearance by microglia via Fc receptor-mediated phagocytosis. Dysfunctions of microglia may play a pivotal role in AD pathogenesis and could result in reduced efficacy of antibody-mediated Aβ clearance. Recently,...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2015
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2015.37